Recombinant proteins containing the hypervariable region of the haemagglutinin protect chickens against challenge with Avibacterium paragallinarum.

@article{Wu2011RecombinantPC,
  title={Recombinant proteins containing the hypervariable region of the haemagglutinin protect chickens against challenge with Avibacterium paragallinarum.},
  author={Jin-Ru Wu and Yi-Ru Wu and Jui-Hung Shien and Yuan-Man Hsu and Chih-Feng Chen and Happy K Shieh and Poa-chun Chang},
  journal={Vaccine},
  year={2011},
  volume={29 4},
  pages={660-7}
}
The haemagglutinin (HA) protein plays a key role in the immunogenicity and pathogenicity of Avibacterium paragallinarum, but the domain organization and antigenicity exhibited by different domains of this protein remain unknown. This study reports the presence of a hypervariable region in the HA proteins of strains of serovars A and C of A. paragallinarum. This hypervariable region is located approximately at residues 1100-1600 of the HA protein. The sequence identity found in this… CONTINUE READING

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