Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin 1.

@article{Charley1990RecombinantPI,
  title={Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin 1.},
  author={Bernard Charley and S Laverne and Laurence Lavenant},
  journal={Veterinary immunology and immunopathology},
  year={1990},
  volume={25 2},
  pages={117-24}
}
The effect of recombinant porcine interferon-gamma (rPoIFN gamma) on in vitro production of interleukin 1 (IL-1) by porcine blood monocytes was studied. Three-day-old cultures of porcine adherent blood mononuclear cells were treated by doses of rPoIFN gamma for 3 or 6 days before lipopolysaccharide (LPS)-induction. While rPoIFN gamma alone had no effect, a combined treatment by rPoIFN gamma and LPS enhanced the IL-1 secretory potential of adherent mononuclear cells and, to a lesser extent, the… CONTINUE READING