Recombinant polymeric IgG anti-Rh: a novel strategy for development of direct agglutinating reagents.


Anti-Rh alloantibodies are used in research and clinic laboratories to define the Rh antigenic profile of human blood samples. IgM anti-Rh antibodies directly agglutinate Rh-positive RBCs. Anti-Rh antibodies of the IgG isotype bind to Rh antigens with a higher intrinsic affinity than IgM and sensitize RBCs, but do not induce direct hemagglutination. The aim… (More)
DOI: 10.1016/j.jim.2008.09.011


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