Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction.

@article{Rothenbach2004RecombinantPG,
  title={Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction.},
  author={Patricia A Rothenbach and Benny Dahl and Jason J. Schwartz and Grant E O'keefe and Masaya Yamamoto and William M. F. Lee and J. Wright Horton and Helen L. Yin and Richard H. Turnage},
  journal={Journal of applied physiology},
  year={2004},
  volume={96 1},
  pages={25-31}
}
Reduced plasma concentrations of the extracellular actin-binding proteins gelsolin and Gc-globulin correlate with pulmonary failure and death in humans after injury. The purpose of this study was to investigate the role of plasma gelsolin in the pathophysiology of inflammation-induced lung injury. We postulated that plasma gelsolin levels decrease at an early time point after burn injury and that the intravenous infusion of gelsolin prevents burn-induced pulmonary microvascular dysfunction… CONTINUE READING

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