Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice.

@article{Plaisant2003RecombinantP5,
  title={Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice.},
  author={Frank Plaisant and Andr{\'e} Clippe and Delphine Vander Stricht and Bernard Knoops and Pierre Gressens},
  journal={Free radical biology & medicine},
  year={2003},
  volume={34 7},
  pages={862-72}
}
The pathophysiology of brain lesions associated with cerebral palsy is multifactorial and likely involves excess release of glutamate and excess production of free radicals, among other factors. Theoretically, antioxidants could limit the severity of these brain lesions. Peroxiredoxins are a family of peroxidases widely distributed in eukaryotes and prokaryotes. Peroxiredoxin 5 (PRDX5) is a recently discovered mammalian member of this family of antioxidant enzymes that is able to reduce… CONTINUE READING
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