Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge.

@article{Tompkins2007RecombinantPV,
  title={Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge.},
  author={Stephen M Tompkins and Yuan Lin and George P. Leser and Kari A Kramer and Debra L Haas and Elizabeth W. Howerth and Jie Xu and Mary J. Kennett and Russell K. Durbin and Joan E Durbin and Ralph Tripp and Robert A. Lamb and Biao He},
  journal={Virology},
  year={2007},
  volume={362 1},
  pages={
          139-50
        }
}
Parainfluenza virus type 5 (PIV5), formerly known as simian virus 5 (SV5), is a non-segmented negative strand RNA virus that offers several advantages as a vaccine vector. PIV5 infects many cell types causing little cytopathic effect, it replicates in the cytoplasm of infected cells, and does not have a DNA phase in its life cycle thus avoiding the possibility of introducing foreign genes into the host DNA genome. Importantly, PIV5 can infect humans but it is not associated with any known human… CONTINUE READING
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