Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice.

@article{Wu2011RecombinantOA,
  title={Recombinant osteopontin attenuates brain injury after intracerebral hemorrhage in mice.},
  author={Bihua Wu and Qingyi Ma and Hidenori Suzuki and Chunhua Chen and Wenwu Liu and Jiping Tang and John H Zhang},
  journal={Neurocritical care},
  year={2011},
  volume={14 1},
  pages={
          109-17
        }
}
BACKGROUND Osteopontin (OPN), an extracellular matrix glycoprotein, has been reported to inhibit inducible nitric oxide synthase (iNOS). We examined if recombinant OPN (r-OPN) inhibits iNOS and prevents brain injury in a mouse collagenase-induced intracerebral hemorrhage (ICH) model. METHODS One hundred one mice were randomly assigned to five groups: sham, ICH + vehicle, ICH + r-OPN (10, 50, or 100 ng per mouse) groups. Vehicle or r-OPN was administered via an intracerebroventricular infusion… CONTINUE READING
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