Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.

@article{Dobrikova2008RecombinantOP,
  title={Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.},
  author={Elena Y. Dobrikova and Trevor L. Broadt and Judith Poiley-Nelson and Xiaoyi Yang and Gopalan Soman and Steve Giardina and Ray Harris and Matthias Gromeier},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2008},
  volume={16 11},
  pages={
          1865-72
        }
}
Many viruses, either naturally occurring or as a result of genetic manipulation, exhibit conditional replication in transformed cells. This principle is the basis for experimental therapeutic approaches exploiting the oncolytic potential of such agents without the danger of collateral damage to resistant normal tissues. One of the potential obstacles to these approaches is the possibility of genetic adaptation of oncolytic viruses upon replication in susceptible tumor tissues. Genetic variation… CONTINUE READING

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