Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury.

@article{Hamrick2010RecombinantM,
  title={Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury.},
  author={Mark W Hamrick and Phonepasong Arounleut and Ethan L Kellum and Matthew S. Cain and David M Immel and Li-fang Liang},
  journal={The Journal of trauma},
  year={2010},
  volume={69 3},
  pages={579-83}
}
BACKGROUND Myostatin (GDF-8) is known as a potent inhibitor of muscle growth and development, and myostatin is also expressed early in the fracture healing process. The purpose of this study was to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in cases of deep penetrant injury. METHODS We used a fibula osteotomy model with associated damage to lateral compartment muscles (fibularis longus… CONTINUE READING

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