Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model.

@article{ElGogo2007RecombinantMG,
  title={Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model.},
  author={Susanne El-Gogo and Caroline Staib and Marcus Meyr and Volker Erfle and Gerd Sutter and Heiko Adler},
  journal={Vaccine},
  year={2007},
  volume={25 20},
  pages={3934-45}
}
Efficient vaccines against AIDS, Hepatitis C and other persistent virus infections are urgently needed. Vaccine development has been especially hampered by the lack of suitable small animal models to reliably test the protective capacity of candidate vaccines against such chronic viral infections. A natural mouse pathogen such as MHV-68 that persists lifelong after infection, appears to be a particularly promising candidate for a more relevant model system. Here, we investigated infections with… CONTINUE READING