Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.

@article{Wolfersttter2014RecombinantMV,
  title={Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.},
  author={Michael Wolferst{\"a}tter and Marc Schweneker and Michaela Sp{\"a}th and Susanne Lukassen and Marieken Klingenberg and Kay Brinkmann and Ursula Wielert and Henning Lauterbach and Hubertus Hochrein and Paul J. Chaplin and Mark Suter and J{\"u}rgen Hausmann},
  journal={Journal of virology},
  year={2014},
  volume={88 24},
  pages={14396-411}
}
UNLABELLED Double-stranded RNA (dsRNA) is an important molecular pattern associated with viral infection and is detected by various extra- and intracellular recognition molecules. Poxviruses have evolved to avoid producing dsRNA early in infection but generate significant amounts of dsRNA late in infection due to convergent transcription of late genes. Protein kinase R (PKR) is activated by dsRNA and triggers major cellular defenses against viral infection, including protein synthesis shutdown… CONTINUE READING
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