Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression.

Abstract

We developed a scalable procedure to produce human mitochondrial transcription factor A (TFAM) modified with an N-terminal protein transduction domain (PTD) and mitochondrial localization signal (MLS) that allow it to cross membranes and enter mitochondria through its "mitochondrial transduction domain" (MTD=PTD+MLS). Alexa488-labeled MTD-TFAM rapidly… (More)
DOI: 10.1016/j.mito.2009.01.012

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Cite this paper

@article{Iyer2009RecombinantMT, title={Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression.}, author={Shilpa S. Iyer and Ravindar R. Thomas and Francisco R. Portell and Lisa D. Dunham and Caitlin K. Quigley and James P. Bennett}, journal={Mitochondrion}, year={2009}, volume={9 3}, pages={196-203} }