Recombinant mannan-binding lectin (MBL) for therapy.

  title={Recombinant mannan-binding lectin (MBL) for therapy.},
  author={Jens Christian Jensenius and Pia Hoennerup Jensen and Kirsty McGuire and Jens Laurits Larsen and Steffen Thiel},
  journal={Biochemical Society transactions},
  volume={31 Pt 4},
Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. Clinical evidence indicates that in a variety of situations genetically determined low MBL levels are associated with increased susceptibility to infections. Infusions of plasma-derived MBL into MBL-deficient individuals was found to be safe in preliminary trials, but… CONTINUE READING

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  • S. V. Petersen, S. Thiel, L. Jensen., R. Steffensen, J. C. Jensenius
  • Allergy Immunol .
  • 1995

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