Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.

  title={Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.},
  author={Patrick C. N. Rensen and Remco L A de Vrueh and J. J. W. Kuiper and Martin K. Bijsterbosch and Erik A. L. Biessen and Th J C van Berkel},
  journal={Advanced drug delivery reviews},
  volume={47 2-3},
Lipoproteins are endogenous particles that transport lipids through the blood to various cell types, where they are recognised and taken up via specific receptors. These particles are, therefore, excellent candidates for the targeted delivery of drugs to various tissues. For example, the remnant receptor and the asialoglycoprotein receptor (ASGPr), which are uniquely localised on hepatocytes, recognise chylomicrons and lactosylated high density lipopoteins (HDL), respectively. In addition… CONTINUE READING


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