Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution.

@article{Wakefield1990RecombinantLT,
  title={Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution.},
  author={Lalage M. Wakefield and T. Winokur and R S Hollands and Kent W. Christopherson and Arthur D. Levinson and Michael B. Sporn},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 6},
  pages={1976-84}
}
Transforming growth factor beta 1 (TGF-beta 1) is a key regulator of cell growth and differentiation. Under normal physiological conditions, it is made as a biologically latent complex whose significance is unknown. Previous work has indicated that active TGF-beta 1 has a very short plasma half-life in rats (Coffey, R. J., L. J. Kost, R. M. Lyons, H. L. Moses, and N. F. La-Russo. 1987. J. Clin. Invest. 80:750-757). We have investigated the possibility that latent complex formation may extend… CONTINUE READING