Recombinant interleukin 4 promotes the growth of human T cells.

  title={Recombinant interleukin 4 promotes the growth of human T cells.},
  author={Hergen Spits and Hans Yssel and Y. Takebe and Naoko Arai and Takafumi Yokota and Fan Lee and Ken-ichi Arai and Jacques Banchereau and Jan de Vries},
  journal={Journal of immunology},
  volume={139 4},
Recently, we reported the isolation of a cDNA clone that encodes a polypeptide which has B cell and T cell growth factor activities. The amino acid sequence of this polypeptide deduced from the nucleotide sequence of the cDNA clone showed significant homology with mouse B cell stimulating factor-1. Because of its multiple biologic activities, it was designated interleukin 4 (IL-4). Here we describe the effects of supernatants of Cos-7 mouse cells transfected with the IL-4 coding cDNA clone in a… CONTINUE READING