Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection.

@article{Wagner1994RecombinantIE,
  title={Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection.},
  author={R Doug Wagner and Howard N. Steinberg and James F. Brown and Charles J. Czuprynski},
  journal={Microbial pathogenesis},
  year={1994},
  volume={17 3},
  pages={175-86}
}
The effect of recombinant murine IL-12 (rIL-12) or anti-IL-12 antibody administration on resistance to murine listeriosis was investigated. Mice given a single 0.5 micrograms dose of rIL-12 had 1.5 log10 fewer listeriae in their spleens and livers as compared with control infected mice 3 days after L. monocytogenes challenge. Conversely, administration of anti-IL-12 IgG caused an equivalent increase in the cfu of L. monocytogenes recovered from the spleens and livers as compared to control mice… CONTINUE READING

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