Recombinant interferon gamma therapy for atopic dermatitis.

  title={Recombinant interferon gamma therapy for atopic dermatitis.},
  author={Jon M. Hanifin and Lynda C. Schneider and Donald Y. M. Leung and Charles N. Ellis and Howard S. Jaffe and Allen E. Izu and Louis R Bucalo and S E Hirabayashi and Susan J Tofte and G Cantu-Gonzales},
  journal={Journal of the American Academy of Dermatology},
  volume={28 2 Pt 1},
BACKGROUND Atopic dermatitis is characterized by immunologic abnormalities including evidence for reduced interferon gamma production. Therapeutic options for treatment of atopic dermatitis are limited and unsatisfactory. Previous open trials have suggested efficacy for recombinant interferon-gamma (rIFN-gamma) in treatment of severe atopic dermatitis. We describe the results of treatment with rIFN-gamma, assessing clinical, immunologic, and laboratory safety parameters in 83 patients with… CONTINUE READING


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