Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice

@article{Tian2014RecombinantHT,
  title={Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice},
  author={Li Tian and Huang Nie and Yang Zhang and Yan Chen and Zheng-wu Peng and Min Cai and Haidong Wei and Pei Qin and Hailong L. Dong and Lize Xiong},
  journal={Neuropharmacology},
  year={2014},
  volume={77},
  pages={453-464}
}
Cerebral ischemia (CI) can induce loss of hippocampal neurons, causing cognitive dysfunction such as learning and memory deficits. In adult mammals, the hippocampal dentate gyrus contains neural stem cells (NSCs) that continuously generate newborn neurons and integrate into the pre-existing networks throughout life, which may ameliorate cognitive dysfunction following CI. Recent studies have demonstrated that recombinant human thioredoxin-1 (rhTrx-1) could promote proliferation of human adipose… CONTINUE READING

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