Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways.

@article{Noda2003RecombinantHS,
  title={Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways.},
  author={Mami Noda and Satsuki Yasuda and Mitsuko Okada and Haruhiro Higashida and Aki Shimada and Nakao Iwata and Norio Ozaki and Kaori Nishikawa and Sakiko Shirasawa and Mayumi Uchida and Shunsuke Aoki and Keiji Wada},
  journal={Journal of neurochemistry},
  year={2003},
  volume={84 2},
  pages={
          222-32
        }
}
Human serotonin 5A (5-HT5A) receptors were stably expressed in undifferentiated C6 glioma. In 5-HT5A receptors-expressing cells, accumulation of cAMP by forskolin was inhibited by 5-HT as reported previously. Pertussis toxin-sensitive inhibition of ADP-ribosyl cyclase was also observed, indicating a decrease of cyclic ADP ribose, a potential intracellular second messenger mediating ryanodine-sensitive Ca2+ mobilization. On the other hand, 5-HT-induced outward currents were observed using the… CONTINUE READING
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