Recombinant human monoclonal antibodies to human cytomegalovirus glycoprotein B neutralize virus in a complement-dependent manner.

@article{Ohta2009RecombinantHM,
  title={Recombinant human monoclonal antibodies to human cytomegalovirus glycoprotein B neutralize virus in a complement-dependent manner.},
  author={Akane Ohta and Ayano Fujita and Tsugiya Murayama and Yoshitaka Iba and Yoshikazu Kurosawa and Tetsushi Yoshikawa and Yoshizo Asano},
  journal={Microbes and infection},
  year={2009},
  volume={11 13},
  pages={
          1029-36
        }
}
Human antibodies specific for HCMV are currently considered as potential anti-HCMV therapeutic agents. In this study, we used a combinatorial human antibody library to isolate and characterize complete human monoclonal antibodies that effectively neutralize HCMV in a complement-dependent manner. One hundred and six clones were isolated in two independent screens using HCMV virions and recombinant glycoprotein B, gB654, as antigens. All of the clones recognized the same molecule gB and were… CONTINUE READING