Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates.

@article{Farese1995RecombinantHM,
  title={Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates.},
  author={Ann M Farese and Pamela M. Hunt and Tom Boone and Thomas J Macvittie},
  journal={Blood},
  year={1995},
  volume={86 1},
  pages={54-9}
}
Megakaryocyte growth and development factor (MGDF) is a novel cytokine that binds to the c-mpl receptor and stimulates megakaryocyte development in vitro and in vivo. This report describes the ability of recombinant human (r-Hu) MGDF to affect megakaryocytopoiesis in normal nonhuman primates. r-HuMGDF was administered subcutaneously to normal, male rhesus monkeys once per day for 10 consecutive days at dosages of 2.5, 25, or 250 micrograms/kg of body weight. Bone marrow and peripheral blood… CONTINUE READING

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