Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells.

@article{Miyazaki2008RecombinantHL,
  title={Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells.},
  author={Takamichi Miyazaki and Sugiko Futaki and Kouichi Hasegawa and Miwa Kawasaki and Noriko Sanzen and Maria Hayashi and Eihachiro Kawase and Kiyotoshi Sekiguchi and Norio Nakatsuji and Hirofumi Suemori},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={375 1},
  pages={27-32}
}
Human embryonic stem cells (hESCs) are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin (rhLM) isoforms on the undifferentiated growth of hESCs. We first determined the major integrins expressed on the hESCs to reveal the preference of the hESCs for rhLMs, and found that the hESCs mainly expressed… CONTINUE READING

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