Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

@article{Quagliarello1991RecombinantHI,
  title={Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.},
  author={Vincent J. Quagliarello and Brian Wispelwey and Wende Long and William Michael Scheld},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 4},
  pages={1360-6}
}
The diversity of infectious agents capable of inducing meningitis and blood-brain barrier (BBB) injury suggests the potential for a common host mediator. The inflammatory polypeptides, IL-1 and TNF, were tested in an experimental rat model as candidate mediators for induction of meningitis and BBB injury. Intracisternal challenge of rIL-1 beta into rats induced neutrophil emigration into cerebrospinal fluid (CSF) and significantly increased BBB permeability to systemically administered 125I-BSA… CONTINUE READING
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