Recombinant human growth hormone and recombinant human insulin-like growth factor I diminish the catabolic effects of hypogonadism in man: metabolic and molecular effects.

@article{Hayes2001RecombinantHG,
  title={Recombinant human growth hormone and recombinant human insulin-like growth factor I diminish the catabolic effects of hypogonadism in man: metabolic and molecular effects.},
  author={V Y Hayes and Randall James Urban and Jie Jiang and Taylor J Marcell and K Helgeson and Nelly Mauras},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 5},
  pages={2211-9}
}
Severe gonadal androgen deficiency can have profound catabolic effects in man. Hypogonadal men develop a loss of lean body mass, increased adiposity, and decreased muscle strength despite normal GH and insulin-like growth factor I (IGF-I) concentrations. We designed these studies to investigate whether GH or IGF-I administration to male subjects with profound hypogonadism can diminish or abolish the catabolic effects of testosterone deficiency. Moreover, we also examined the nature of the… CONTINUE READING

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