Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia

  title={Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia},
  author={Min-Suk Yoon and Lars P Bechmann and Mark Obermann and Olivia Yepnjouo and Rupert Egensperger and Guido G H Gerken and Zaza Katsarava and Juergen Thomale and Gerald Holtmann},
  journal={Neuroscience Bulletin},
Cisplatin exerts its cytotoxic effect through distinct DNA lesions, leading to peripheral neuropathy. The risk of sensory neuropathy is a common problem during cancer treatment with cisplatin, leading to somatic hyperalgesia. Yet, data focussing on cisplatin-induced impairment of the autonomic nervous system are limited. The present study was aimed to investigate the effect of recombinant human erythropoietin (rhEPO) on cisplatin-induced visceral hyperalgesia. C57BL/6 mice were treated either… CONTINUE READING