Recombinant human erythropoietin: 10 years of clinical experience.

@article{Winearls1998RecombinantHE,
  title={Recombinant human erythropoietin: 10 years of clinical experience.},
  author={Christopher G. Winearls},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1998},
  volume={13 Suppl 2},
  pages={3-8}
}
The need for a renewable source of erythropoietin to treat the anaemia of chronic renal failure was first recognized in the 1960s, but cloning and expression of the human gene was not achieved until 1983. Clinical testing of recombinant human erythropoietin (r-HuEPO) began in 1985, leading to the first licence as a therapeutic agent in 1988. The first clinical trials showed that an intravenous dose requirement of about 200 IU/kg/week would increase haemoglobin concentrations to 10-12g/dl in >90… CONTINUE READING

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