Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning.

@article{Huang2007RecombinantHB,
  title={Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning.},
  author={Yue-Jin Huang and Yue Huang and Hernan Baldassarre and Bin Wang and Anthoula Lazaris and Martin Leduc and Annie S Bilodeau and Annie Bellemare and M{\'e}lanie C{\^o}t{\'e} and Peter Herskovits and Madjid Touati and Carl Turcotte and Loredana Valeanu and Nicolas Lem{\'e}e and Harvey Wilgus and Isabelle B{\'e}gin and Bhim Bhatia and K. Santosh Mohan Rao and Nathalie Neveu and Eric Brochu and Janice Pierson and Duncan K. Hockley and Douglas M. Cerasoli and David Lenz and Costas N. Karatzas and Solomon Langermann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 34},
  pages={13603-8}
}
Dangerous organophosphorus (OP) compounds have been used as insecticides in agriculture and in chemical warfare. Because exposure to OP could create a danger for humans in the future, butyrylcholinesterase (BChE) has been developed for prophylaxis to these chemicals. Because it is impractical to obtain sufficient quantities of plasma BChE to treat humans exposed to OP agents, the production of recombinant BChE (rBChE) in milk of transgenic animals was investigated. Transgenic mice and goats… CONTINUE READING
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