Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft?

@article{Szpalski2005RecombinantHB,
  title={Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft?},
  author={Marek Szpalski and Robert Gunzburg},
  journal={Acta orthopaedica Belgica},
  year={2005},
  volume={71 2},
  pages={133-48}
}
Autogenous bone grafts from the iliac crest have long been the gold standard for repair and reconstruction of bone; however harvesting of the grafts from the iliac crest is associated with donor site morbidity, particularly chronic pain. The bone morphogenetic proteins (BMPs) are soluble bone matrix glycoproteins that induce the differentiation of osteoprogenitor cells into osteogenic cells and have the potential to act as autogenous bone graft substitutes. BMP-2, which can be produced with… CONTINUE READING

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rhBMP-2 versus autogenous bone graft

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