Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli.

@article{Minnema2000RecombinantHA,
  title={Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli.},
  author={Monique C. Minnema and Alvin C K Chang and Patty Micha{\"e}la Jansen and Yvonne T P Lubbers and Bruce Pratt and Becky G Whittaker and Fletcher B. Taylor and C. Erik Hack and Boris Friedman},
  journal={Blood},
  year={2000},
  volume={95 4},
  pages={1117-23}
}
Plasma-derived antithrombin III (ATIII) prevents the lethal effects of Escherichia coli infusion in baboons, but the mechanisms behind this effect are not clear. In the present study, we evaluated the effects of recombinant human ATIII (rhATIII) on the clinical course and the inflammatory cytokine and coagulation responses in baboons challenged with lethal dose of E coli. Animals in the treatment group (n = 5) received high doses of rhATIII starting 1 hour before an E coli challenge. Those in… CONTINUE READING
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