Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis.

@article{Kanji2001RecombinantHA,
  title={Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis.},
  author={Salmaan Kanji and John W. Devlin and K A Piekos and Eric Racine},
  journal={Pharmacotherapy},
  year={2001},
  volume={21 11},
  pages={1389-402}
}
Sepsis remains a major cause of death in hospitalized patients. Despite a massive research effort over the past 2 decades to identify innovative therapies for sepsis, current treatment strategies consist primarily of antiinfective agents and a variety of supportive measures. Activated protein C, an endogenous protein that inhibits thrombosis and inflammation while promoting fibrinolysis, plays an important role in the pathogenesis of sepsis. Recombinant human activated protein C, drotrecogin… CONTINUE READING