Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study.

@article{Dhooghe2006RecombinantHT,
  title={Recombinant human TNFRSF1A (r-hTBP1) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo- and drug-controlled study.},
  author={Thomas D'hooghe and Noreen P Nugent and S Peder Cuneo and Daniel C Chai and Frank Deer and Sophie Debrock and Cleophas Mutinda Kyama and Attila Mih{\'a}lyi and Jason M. Mwenda},
  journal={Biology of reproduction},
  year={2006},
  volume={74 1},
  pages={131-6}
}
Endometriosis is associated with chronic inflammation, including an increased macrophage activity with increased secretion of cytokines, such as tumor necrosis factor (TNF) or TNF superfamily member 2, previously known as TNFalpha. In the present study, we tested the hypothesis that recombinant human TNFRSF1A (r-hTBP1) can inhibit the development of endometriotic lesions in the baboon, an established model for the study of endometriosis. Endometriosis was induced using intrapelvic injection of… CONTINUE READING

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