Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice

@article{Zhang2015RecombinantHM,
  title={Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice},
  author={Yinzhong Zhang and Max Brenner and Weng-Lang Yang and Ping Wang},
  journal={Laboratory Investigation},
  year={2015},
  volume={95},
  pages={480-490}
}
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive system and typically requires lifelong medical care. Recombinant human MFG-E8 (rhMFG-E8) is a 364-amino acid protein, which promotes apoptotic cell clearance and reduces inflammation. This study investigates the therapeutic effect of rhMFG-E8 on two well-established mouse models of IBD. Acute mucosal injury leading to colitis was caused by exposing C57BL/6 mice to 4% dextran sodium sulfate (DSS) in the… Expand
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