Recombinant human IL-16 inhibits HIV-1 replication and protects against activation-induced cell death (AICD).

@article{Idziorek1998RecombinantHI,
  title={Recombinant human IL-16 inhibits HIV-1 replication and protects against activation-induced cell death (AICD).},
  author={Thierry Idziorek and Jamal Khalife and O. Billaut-Mulot and Eva Hermann and Marc Aumercier and Yves Mouton and Andr{\'e} Capron and Georges M. Bahr},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={112 1},
  pages={84-91}
}
The chemoattractant cytokine IL- 16 has been reported to suppress lymphocyte activation and to inhibit HIV-1 replication in acutely infected T cells. We have cloned and expressed human IL-16 in Escherichia coli and investigated whether the recombinant protein could regulate the level of lymphocyte apoptosis from HIV-1-infected subjects. After purification and refolding, only 2-10% of the recombinant cytokine was present in a biologically active homotetrameric form. This could explain the need… CONTINUE READING