Recombinant human C5a-induced bronchoconstriction in the guinea pig: inhibition by an H1 antagonist after depletion of circulating granulocytes and platelets.

Abstract

Recombinant human C5a (rHuC5a) causes an intense bronchoconstriction very quickly after i.v. injection into the guinea pig. In addition, it causes a biphasic blood pressure response characterized by a small hypotensive phase followed by a larger transient hypertensive phase. The overall goal was to determine the role of circulating cells in the… (More)

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Cite this paper

@article{Fraser1991RecombinantHC, title={Recombinant human C5a-induced bronchoconstriction in the guinea pig: inhibition by an H1 antagonist after depletion of circulating granulocytes and platelets.}, author={D. Fraser and Joshua Regal}, journal={The Journal of pharmacology and experimental therapeutics}, year={1991}, volume={259 3}, pages={1213-20} }