Recombinant histamine-releasing factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils.

@article{Schroeder1997RecombinantHF,
  title={Recombinant histamine-releasing factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils.},
  author={John T. Schroeder and Lawrence M. Lichtenstein and Susan M Macdonald},
  journal={Journal of immunology},
  year={1997},
  volume={159 1},
  pages={447-52}
}
Human recombinant histamine-releasing factor (HrHRF) is known to directly stimulate histamine release and IL-4 secretion from basophils of selected atopic donors in a reaction requiring the expression of a particular type of IgE, referred to as IgE+. In this study, HrHRF is shown to affect the IgE-mediated release of IL-4, IL-13, and histamine from basophils not normally releasing to this protein (i.e, those expressing IgE-). Priming with several different concentrations of HrHRF for 15 min… CONTINUE READING

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