Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: a 1-year experience in 57 patients.

@article{Koster2000RecombinantHA,
  title={Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: a 1-year experience in 57 patients.},
  author={Andreas Koster and Ross Hansen and Herman Kuppe and Roland Hetzer and George J. Crystal and Fritz Mertzlufft},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={2000},
  volume={14 3},
  pages={243-8}
}
OBJECTIVE To explore the possible use of recombinant hirudin (r-hirudin) as an alternative to heparin for anticoagulation during cardiovascular surgery. DESIGN Retrospective analysis. SETTING Two university hospitals. PARTICIPANTS Fifty-seven patients with heparin-induced thrombocytopenia type II (HIT II) in whom r-hirudin was used during cardiovascular surgery with cardiopulmonary bypass (CPB). INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS The r-hirudin concentration was… CONTINUE READING
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