Recombinant hGH replacement therapy and the hypothalamus-pituitary-thyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism?

@article{Giavoli2003RecombinantHR,
  title={Recombinant hGH replacement therapy and the hypothalamus-pituitary-thyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism?},
  author={C Giavoli and Silvia Porretti and Emanuele Ferrante and Vincenzo Cappiello and Cristina L Ronchi and Pietro Travaglini and Paolo Epaminonda and Maura Arosio and Paolo Beck-Peccoz},
  journal={Clinical endocrinology},
  year={2003},
  volume={59 6},
  pages={806-10}
}
OBJECTIVE Recombinant hGH treatment may alter thyroid hormone metabolism and we have recently reported that 50% of patients with GH deficiency (GHD) due to organic lesions, previously not treated with thyroxine, developed hypothyroidism during treatment with recombinant human GH (rhGH). These results prompted us to evaluate the impact of rhGH treatment on thyroid function in children with GHD. DESIGN Open study of GH treatment up to 12 months. Investigations were performed at baseline, and… CONTINUE READING

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