Recombinant glycoproteins resembling carbohydrate-specific IgE epitopes from plants, venoms and mites

@inproceedings{Gattinger2019RecombinantGR,
  title={Recombinant glycoproteins resembling carbohydrate-specific IgE epitopes from plants, venoms and mites},
  author={Pia Gattinger and Irene Mittermann and Christian Lupinek and Gerhard Hofer and Walter Keller and Ur{\vs}ka Bidovec Stojkovi{\'c} and Peter Koro{\vs}ec and Christine Koessler and Natalija Novak and Rudolph Valenta},
  booktitle={EBioMedicine},
  year={2019}
}
BACKGROUND N-linked glycans present in venoms, pollen and mites are recognized by IgE antibodies from >20% of allergic patients but have low or no allergenic activity. OBJECTIVES To engineer recombinant glycoproteins resembling carbohydrate-specific IgE epitopes from venoms, pollen and mites which can discriminate carbohydrate-specific IgE from allergenic, peptide-specific IgE. METHODS One or two N-glycosylation sites were engineered into the N-terminus of the non-allergenic protein horse… CONTINUE READING
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