Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

@article{Nabel1993RecombinantFG,
  title={Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo},
  author={Elizabeth G. Nabel and Zhi-Yong Yang and Gregory E. Plautz and Reza Forough and Xi Zhan and Christian C. Haudenschild and Thomas Maciag and Gary J. Nabel},
  journal={Nature},
  year={1993},
  volume={362},
  pages={844-846}
}
THE prototype members of the heparin-binding fibroblast growth factor (FGF) family1–6, acidic FGF (FGF-1) and basic FGF (FGF-2), are among the growth factors that act directly on vascular cells to induce endothelial cell growth and angiogenesis. In vivo, the role of the FGF prototypes in vascular pathology has been difficult to determine. We report here the introduction, by direct gene transfer into porcine arteries, of a eukaryotic expression vector encoding a secreted form of FGF-1. This… CONTINUE READING
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