Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes.

@article{Dietzel2017RecombinantFP,
  title={Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes.},
  author={Eileen Dietzel and Julia Floehr and Eddy van de Leur and Ralf Weiskirchen and Willi Jahnen-Dechent},
  journal={Molecular human reproduction},
  year={2017},
  volume={23 1},
  pages={
          25-33
        }
}
STUDY QUESTION Does fetuin-B inhibit premature zona pellucida (ZP) hardening in mouse oocytes in vitro and thus increase IVF rate? SUMMARY ANSWER Supplementation of oocyte in vitro maturation (IVM) media with recombinant mouse fetuin-B (rmFetuB) increased fertilization rate without affecting mouse embryo development into blastocysts. WHAT IS KNOWN ALREADY Mice deficient in fetuin-B are infertile owing to premature ZP hardening. Premature ZP hardening also occurs during oocyte IVM leading to… CONTINUE READING