Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1.

@article{Ho2006RecombinantED,
  title={Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1.},
  author={Siu-hong Ho and Francine Martin and Adrian Higginbottom and Lynda J. Partridge and Varadarajan Parthasarathy and Gregory William Moseley and Peter Lopez and Cecilia Cheng-Mayer and Peter N Monk},
  journal={Journal of virology},
  year={2006},
  volume={80 13},
  pages={6487-96}
}
Human immunodeficiency virus type 1 (HIV-1) infection of human macrophages can be inhibited by antibodies which bind to the tetraspanin protein CD63, but not by antibodies that bind to other members of the tetraspanin family. This inhibitory response was limited to CCR5 (R5)-tropic virus and was only observed using macrophages, but not T cells. Here, we show that recombinant soluble forms of the large extracellular domain (EC2) of human tetraspanins CD9, CD63, CD81, and CD151 produced as fusion… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Similar Papers

Loading similar papers…