Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

@article{Rapizzi2002RecombinantEO,
  title={Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria},
  author={Elena Rapizzi and Paolo Pinton and Gy{\"o}rgy Szabadkai and Mariusz Roman Wieckowski and Gr{\'e}goire Vandecasteele and Geoffrey S. Baird and Richard A. Tuft and Kevin E. Fogarty and Rosario Rizzuto},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={159},
  pages={613 - 624}
}
Although the physiological relevance of mitochondrial Ca2+ homeostasis is widely accepted, no information is yet available on the molecular identity of the proteins involved in this process. Here we analyzed the role of the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane in the transmission of Ca2+ signals between the ER and mitochondria by measuring cytosolic and organelle [Ca2+] with targeted aequorins and Ca2+-sensitive GFPs. In HeLa cells and skeletal myotubes… CONTINUE READING

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