Recombinant expression of rt-PA gene (encoding Reteplase) in gametophytes of the seaweed Laminaria japonica (Laminariales, Phaeophyta)

  title={Recombinant expression of rt-PA gene (encoding Reteplase) in gametophytes of the seaweed Laminaria japonica (Laminariales, Phaeophyta)},
  author={Yichen Zhang and Peng Jiang and Jiangtao Gao and Jianmin Liao and Shijing Sun and Zilong Shen and Song Qin},
  journal={Science in China Series C: Life Sciences},
The life cycle of seaweed Laminaria japonica involves a generation alternation between diploid sporophyte and haploid gametophte. The expression of foreign genes in sporophte has been proved. In this research, the recombinant expression in gametophyte was investigated by particle bombardment with the rt-PA gene encoding the recombinant human tissue-type plasminogen activator (Reteplase), which is a thrombolytic agent for acute myocardial infarction (AMI). Transgenic gametophytes were selected… CONTINUE READING
Highly Cited
This paper has 109 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-9 of 9 extracted citations

110 Citations

Citations per Year
Semantic Scholar estimates that this publication has 110 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 28 references

Stable expression of bar gene in the gametophytes of kelp ( Laminaria japonica )

Z Zhang
High Tech Lett • 2006

Intracellular expression of rPA gene in Pichia pastoris

J Huang, Q Long, S RenQ
Chi J Biochem Pharma • 2003

Stable expression of lacZ reporter gene in seaweed Undaria pinnatifida

P Jiang
High Tech Lett • 2003

Cloning and expression of tissue - type plasminogen activator mutant Reteplase ( rt - PA ) in E . coli

M LiaoJ, J Zhang, L ShenZ
Pharm Biotechnol • 2002

Expression of hepatitis B surface antigen gene ( HBsAg ) in Laminaria japonica ( Laminariales , Phaeophyta )

P Jiang, S Qin, C Tseng
Chin Sci Bull • 2002

Similar Papers

Loading similar papers…