Recombinant expression of bovine LFA-1 and characterization of its role as a receptor for Mannheimia haemolytica leukotoxin.

@article{Dileepan2005RecombinantEO,
  title={Recombinant expression of bovine LFA-1 and characterization of its role as a receptor for Mannheimia haemolytica leukotoxin.},
  author={Thamotharampillai Dileepan and Praveen Thumbikat and Bruce Walcheck and Mathur S Kannan and Samuel K. Maheswaran},
  journal={Microbial pathogenesis},
  year={2005},
  volume={38 5-6},
  pages={249-57}
}
Mannheimia (Pasteurella) haemolytica leukotoxin (LktA) is the primary virulence factor contributing to the pathogenesis of lung injury in bovine pneumonic mannheimiosis (BPM), a disease which causes major economic loss to the US cattle industry annually. Recent work from our laboratory using an antibody-based approach has shown that LktA binds to bovine LFA-1 in target cells. While this study suggests that LFA-1 might be a specific receptor, it remains to be conclusively shown that LFA-1 is… CONTINUE READING

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