Recombinant expression of biologically active murine soluble EPCR.

  title={Recombinant expression of biologically active murine soluble EPCR.},
  author={Jacinto L{\'o}pez-Sagaseta and Ram{\'o}n Montes and Jos{\'e} Hermida},
  journal={Protein expression and purification},
  volume={64 2},
Endothelial cell protein C receptor (EPCR) downregulates the coagulation system and prevents thrombosis by binding to protein C/activated protein C (APC) and factor VII/activated factor VII (VIIa). Recombinant APC and factor VIIa have been shown to be useful in a variety of clinical conditions. Murine models could prove extremely helpful in order to study in vivo actions of these drugs. It is therefore crucial to demonstrate the interaction between these and murine EPCR. We expressed the… CONTINUE READING