Recombinant diabody-based immunocapture enzyme-linked immunosorbent assay for quantification of rabies virus glycoprotein.

@article{Nimmagadda2010RecombinantDI,
  title={Recombinant diabody-based immunocapture enzyme-linked immunosorbent assay for quantification of rabies virus glycoprotein.},
  author={Sridevi V. Nimmagadda and Shukra M. Aavula and Neelakantam Biradhar and Varaprasada Sankarasetty Rao and Rajalakshmi Shanmugham and Dev Chandran and Nagarajan Thirumeni and Nagendrakumar Balasubramanian Singanallur and Srinivasan Alwar Villuppanoor},
  journal={Clinical and vaccine immunology : CVI},
  year={2010},
  volume={17 8},
  pages={
          1261-8
        }
}
The potency of rabies vaccines, determined using the NIH mouse protection test, can be directly correlated to the amount of rabies virus glycoprotein (RV GP) present in the vaccine. In an effort to develop a simple and sensitive enzyme-linked immunosorbent assay (ELISA) using recombinant diabody for quantification of RV GP, the variable heavy (V(H)) and light chain (V(L)) domains of an RV GP-specific human monoclonal antibody (MAb) secreted by a human x mouse heterohybridoma (human MAb R16E5… CONTINUE READING
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