Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.

@article{Fortin2001RecombinantCS,
  title={Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.},
  author={Anny Fortin and Eduardo Diez and Daniel L. Rochefort and Laurent Laroche and Danielle Malo and G A Rouleau and Philippe Gros and Emil Skamene},
  journal={Genomics},
  year={2001},
  volume={74 1},
  pages={21-35}
}
Complex genetic traits can be dissected in mice, using well-defined sets of recombinant inbred strains, congenic strains, and recombinant congenic strains (RCS). We report the creation of a series of 37 independent RCS derived from the commonly used inbred strains of laboratory mouse A/J (A) and C57BL/6J (B6). These RCS were derived by systematic inbreeding of independent pairs of animals from a (F1 x A) x A and a (F1 x B) x B double backcross (N3), to create AcB and BcA strains, respectively… CONTINUE READING
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