Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.

@article{Daniels2008RecombinantCM,
  title={Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.},
  author={Melvin D. Daniels and Kenneth V Hyland and Kegiang Wang and David M. Engman},
  journal={Autoimmunity},
  year={2008},
  volume={41 6},
  pages={490-9}
}
The specificity and function of T helper (Th) immune responses underlying the induction, progression, and resolution of experimental autoimmune myocarditis (EAM) in A/J mice are unclear. Published data suggest involvement of both Th1 and Th2 responses in EAM; however, the previous inability to assess antigen-specific in vivo and in vitro T-cell responses in cardiac myosin-immunized animals has confounded our understanding of this important model of autoimmune myocarditis. The goal of our study… CONTINUE READING

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