Recombinant bovine soluble CD14 reduces severity of experimental Escherichia coli mastitis in mice.

@article{Lee2003RecombinantBS,
  title={Recombinant bovine soluble CD14 reduces severity of experimental Escherichia coli mastitis in mice.},
  author={J W Lee and Max J. Paape and Xin Zhao},
  journal={Veterinary research},
  year={2003},
  volume={34 3},
  pages={307-16}
}
Endotoxin, or lipopolysaccharide (LPS), is responsible for pathogenesis of infections induced by Gram-negative bacteria, such as E. coli. The cellular response to LPS is modulated by interactions among LPS, LPS-binding protein (LBP) and CD14. Accumulated evidence shows that the soluble form of CD14 (sCD14) competes with membrane-bound CD14 (mCD14) for LPS and plays a pivotal role in regulating bacterial infection and septic shock caused by Gram-negative bacteria. Recombinant bovine sCD14… CONTINUE READING
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Elevated soluble CD14 in bovine milk after intramammary 316 J.-W. Lee et al. challenge with Escherichia coli lipopolysaccharide

  • J. Lee, X. Zhao, M. J. Paape
  • FASEB J
  • 2002
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